Urinary Health

PETdiatric Laboratories UTI-oxi uses the cranberry extract produced using a Biosfered Srl proprietary technology is first titrated with the DMAC method to obtain the total amount of PACs and subsequently is analyzed by liquid chromatography coupled to mass spectrometry (HPLC-ESI-MS/MS) for the assessment of the content of the PAC A (and the possible presence of PAC B).

The berries of cranberry are used since hundreds of years as a remedy for diseases of the urinary tract and have attracted attention due to their potential health benefits. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PAC) with A-type linkages were isolated from cranberry which exhibit bacterial anti-adhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The phytochemicals associated with cranberry bioactivity include flavonoids, phenolic acid derivatives, hydroxycinnamic acid derivatives, organic acids, and isoprenoids (including ursolic acid and lutein). Among phenols are flavonols, anthocyanins and proanthocyanidins (PACs), catechins or flavan-3-ols.

 

PETdiatric Laboratories UTI-oxi is formulated with the highest content of PAC A on the market. Blended with a patented ingredient Oximacro®, it offers protection against bacterial adhesion and virulence in the urinary tract. Oximacro® is a cranberry extract characterized by a high content of Type A PACs which are the only proanthocyanidins bioactive against UTI.